CURRICULUM VITAE                                                                                               January 1, 2007

 

LAWRENCE LEE ESPEY, Ph.D.

Ruth C. and Andrew G. Cowles Distinguished Professor of Life Sciences

Department of Biology, Trinity University, San Antonio, TX 78212-7200

tel. (office) (210) 999-7237; tel.  (lab) (210) 999-7234; fax  (univ) (210) 999-7229

e-mail:  lespey@trinity.edu;

website:  www.trinity.edu/lespey

Date and Place of Birth:  September 5, 1935; Mercedes, Texas

Wife:  Doina Ionescu Espey

 

EDUCATION, TRAINING, AND PRACTICAL WORK EXPERIENCE

1954-58:  B.A. Degree, Zoology (Chemistry Minor), The University of Texas, Austin

1959-60:  Departmental Research Assistant, Department of Physiology, Pharmacology, and Biochemistry, University of Texas Dental Branch, Houston. Duties included general assistance to 15 different professors for one year.

1960-61:  M.A. Degree, Zoology (Biochemistry Minor), The University of Texas, Austin

1961-64:  Ph.D. Degree, Physiology, The Florida State University, Tallahassee

1964-66:  NIH Post-Doctoral Fellow, Dept. of Physiology, Univ. Michigan Medical School, Ann Arbor

 

POSITIONS WITH FACULTY STATUS

1964:        Instructor, Dept of Biological Sciences, Div. of Physiology, Florida State University, Tallahassee

1966-70:  Assistant Professor, Department of Biology, Trinity University, San Antonio

1970-74:  Associate Professor, Department of Biology, Trinity University, San Antonio

1974-01:  Professor, Department of Biology, Trinity University, San Antonio

2002-06:  Cowles Distinguished Professor of Life Sciences, Trinity University, San Antonio

 

CONTINUING EDUCATION VIA SABBATICALS AND WORKSHOP EXPERIENCES

1981:  Participant: The Endocrine Society’s 10th Training Course on Hormone Assay. Boston, MA.

1983:  Guest Research Scholar: Department of Obstetrics & Gynecology, Kyoto University, Japan.

1984:  Visiting Professor: Department of Pharmacology, Medical University of South Carolina, Charleston.

1990:  Participant: Molecular Endocrinology Workshop, Baylor College of Medicine, Houston.

1993:  Participant: New England Biolab Molecular Biology Workshop, Smith College, Northampton, MA.

1993:  Visiting Professor: Department of Cell Biology, Baylor College of Medicine, Houston.

1996:  Visiting Professor: Department of Obstetrics & Gynecology, Shinshu University, Japan.

1997:  Participant: Differential Display Workshop, Vanderbilt University Medical Center, Nashville.

2001:  Visiting Professor: Department of Gynecology & Obstetrics, Kyoto University, Japan.

 

PRINCIPAL PROFESSIONAL SOCIETY MEMBERSHIPS

1967---:  The American Physiological Society

1978---:  The Endocrine Society

1963---:  The Society for the Study of Reproduction (Charter Member)

 

PRINCIPAL RESEARCH AND ACADEMIC INTERESTS

The Physiology of Mammalian Ovulation, and General Function of the Ovary

The Biochemistry of Inflammatory Reactions, with emphasis on Acute Inflammatory Reactions

The Application of the Molecular Protocol "Differential Display" to Gene Expression in Ovarian Tissues

The Development of Improved Methods of Contraception and Birth Control

The Growth Rate of the Human Population, and Its Effect on the Global Environment

HONORS AND AWARDS

1964-66:  NIH Post-Doctoral Fellowship

1970:  Outstanding Young Men of America

1973:  Invited Lecturer: Symposium on Ovulation, Society for the Study of Reproduction, Athens, GA.

1974:  Invited Lecturer: Symposium on Proteases and Biological Control, Cold Spring Harbor, NY.

1976:  Invited Participant, Scholar-Diplomat Program in Population Affairs, Dept. of State, Washington DC.

1977:  Keynote Address: 1st National Symposium on Reproduction in Animals Bucharest, Romania.

1977-79:  Fulbright-Hays Senior Research Award to Romania.

1979-82:  Ruth B. and Andrew G. Cowles Professor of Life Sciences at Trinity University.

1983:  Featured Lecturer: The Japanese Fertility Society Regional Meeting, Osaka, Japan.

1989:  Invited Lecturer: Serono Symposium on Follicular Development and Ovulation, Tiberias, Israel.

1990:  Invited Lecturer: IInd Sapporo International Symposium on Ovarian Function, Hokkaido, Japan..

1991:  Invited Lecturer: Fernstrom Symposium on Local Regulation of Ovarian Function, Lund, Sweden.

1993:  Invited Lecturer: Symposium. on Ovarian Function, SSR, Fort Collins, CO.

1995:  Keynote Address, 45th Kyushu Meeting of the Japan Society of Obstet/Gynec, Kumamoto, Japan.

1995:  Invited Lecturer: 2nd International Malpighi Symposium, Rome, Italy.

1996:  Presentation Award from GenHunter Corporation for paper presented at Symposium.on Differential Display and Related Techniques for Gene Discovery, Cold Spring Harbor Laboratory, NY.

1996:  Honorary Member of Dept. of Obstet/Gynec, Shinshu Univ. School of Medicine, Matsumoto Japan.

1998:  Keynote Address: International Serono Symposium on Ovulation, Salt Lake City, UT.

1998:  Invited Speaker at Distinguished Scientist Seminar, Oregon Health Science University, Portland, OR.

1999:  Keynote Address, Japanese Conference on Fertilization and Implantation, Kumamoto, Japan.

2001:  Invited Lecturer: SSR Symposium on Signaling Processes during the Peri-Ovulatory Period, Ottawa, Canada

2002:  First Recipient of the Trinity University Award for Distinguished Achievement in Research Scholarship.

2002:  Award for Best Oral Presentation at the 3rd International Symposium on Differential Gene Expression, 2002.  Vanderbilt Medical Center, Nashville.

2003:  Invited Speaker at the International Conference on the Ovary 2003, Tokyo, Japan.

2004:  Closing Address at the National Ovarian Workshop of the United Kingdom, University of Edinburgh Royal Infirmary, Scotland.

2004:  Invited Speaker: SSR Symposium on Dynamics of Ovarian Tissue Remodeling and Gene Expression during Folliculogenesis, Ovulation, and Luteogenesis, University of British Columbia, Vancouver, Canada.

2004:  Keynote Address at the 36th Annual Meeting of the Clinical Electron Microscopy Society of Japan, Kumamoto.

2007:  Invited Speaker at the International Conference on the Ovary 2007, Tokyo, Japan

RESEARCH AWARDS AND CONTRACTS FOR BASIC RESEARCH ON OVULATION

1964-66:  NIH Post-Doctoral Fellow, Dept. of Physiology, University of Michigan, Ann Arbor, $15,000

1967-68:  Morrison Trust Grant, "The Physiology of Ovulation", $10,000.

1967-70:  NIH/NICHD Research Grant: "The Chemical Basis of the Ovulatory Process", $141,242.

1969-72:  NIH/NICHD Research Contract: "The Physiology of Ovulation", $120,950.

1972-75:  NIH/NICHD Research Grant: "Dynamics of Ovulation", $160,000.

1976-78:  NIH/NICHD Research Grant: "Dynamics of Ovulation" (renewal), $93,500.

1977-79:  Fulbright-Hays Research Award to Romania: "The Physiology of Ovulation", $25,000.

1980-84:  NIH/NICHD Research Grant: "Ovulation as an Inflammatory Process", $204,000.

1983-84:  Trinity University: "Biochemical Analysis of Ovarian Follicles for Inflammation", $25,000.

1986:       Trinity University: "Ovulation as a Model for Testing Anti-Inflammatory Drugs", $10,000.

1987-92:  NIH/NICHD Research Grant: "Gonadotropin-Induced Ovarian Inflammation", $452,200.

1988-89:  Lalor Foundation: "Role of Leukotriene B4 in the Biochemical Mechanism of Mammalian Ovulation and Effect of Leukotriene Inhibitors on Ovulation", $50,000.

1994-97:  NIH/NICHD Research Grant: "Isolation of mRNAs Unique to Ovulation", $103,000.

1998-02:  NSF Research Grant: "Analysis of Ovarian Gene Expression during Ovulation", $213,000.

1999-00:  Lalor Foundation: Use of Differential Display and Related Molecular Methods to Isolate and Identify Genes in Ovarian Tissue that are Uniquely Expressed during Ovulation in Rats", $25.000.

2000:       American Physiological Society: "Undergrad. Summer Research Fellowship for Jane Healy", $3,300.

2002:       NSF Grant: “RUI:Image Aquisition and Analysis Facility for Faculty-Student Research”, $123,667.

2003-07:  NSF Research Grant: “Gonadotropin-Induced Gene Transcription Associated with Ovulation”, $350,000.

CONSULTING AND OTHER PROFESSIONAL ACTIVITIES

1973:  NIH Site Visit Team Member to the University of Washington School of Medicine, Seattle, WA.

1974:  Member: Awards Committee of the Society for the Study of Reproduction

1975:  Ad Hoc Member: NIH/NICHD Reproductive Biology Study Section, May 9.

1975-91:  Senior Scientist: Ctr. Res. in Reprod. Biol., University of Texas Health Science Center in San Antonio

1976:  Participant: NIH/NICHD Workshop on "The Ovary", June-20-22, Santa Clara, CA.

1983:  Member: ByLaws Committee of the Society for the Study of Reproduction

1984:  Chairman: ByLaws Committee of the Society for the Study of Reproduction

1986:  Consultant: World Health Organization, "Special Program of Research: Development and Research Training in Human Reproduction"

1988-90:  Lecturer: Didactic Program for Fellowship Training in Reproductive Endocrinology and Infertility, Dept. of Obstetrics & Gynecology, The University of Texas Health Science Center at San Antonio.

1990:  Coordinator and Host: Annual Meeting of the Southwest Section of the Society for Experimental Biology and Medicine. Trinity University, October 19.

1993-96:  Review Panelist: National Research Council, Fellowship and Associateship Programs

1994:  Ad Hoc Member: NIH/NICHD Reproductive Biology Study Section

1996:  Ad Hoc Member: NIH/NICHD Reproductive Endocrinology Study Section

1997:  Chairman: Scientific Session on "Ovulation" at the 30th Annual Meeting of the Society for the Study of Reproduction, Portland, OR.

1998:  Review Panel Member: CONRAD Twinning Program for Intl. Research in Contraceptive Development.

2001:  Faculty Opponent for the Ph.D. Dissertation Defense of Markus Matousek, Goteborg University, Department of Obstetrics and Gynecology, Goteborg, Sweden.

 

ORGANIZATIONS FOR WHICH RESEARCH GRANTS HAVE BEEN REVIEWED

National Science Foundation

NIH/National Institute of Child Health and Human Development, Reproductive Biology Study Section

NIH/National Inst. of Child Health and Human Development, Reproductive Endocrinology Study Section

The Harold Wetterberg Foundation, Cornell University

United States Agency for International Development, Conrad Program

United States Department of Agriculture, Animal Science Institute

United States—Israel Binational Agricultural Research and Development Fund

Center for Environmental and Rural Health at Texas A&M University

Wellcome Trust

 

JOURNALS FOR WHICH ARTICLES HAVE BEEN REVIEWED

Endocrinology; Proceedings of the National Academy of Science, USA; American Journal of Physiology; Journal of Reproduction and Fertility; Biology of Reproduction; Molecular Reproduction and Development; Fertility & Sterility; Journal of Biological Chemistry; Protoplasma; European Journal of Cancer Research; The Anatomical Record; Proceedings Society for Experimental Biology & Medicine; Journal of Animal Science; Journal of Experimental Zoology; Prostaglandins; Journal of Endocrinological Investigation; Endocrinological Investigation; Journal of Cell Biology; Connective Tissue Research; BioTechniques; Human Reproduction

 

COMMUNITY ACTIVITIES

1973-76:  Board Member, Citizens for a Better Environment, San Antonio Chapter.

1976:  Lecturer to the Administration of the City Public Service Board of San Antonio on the topic of "The Atomic Energy Museum’s Energy-Environment Simulator, and Its Predictions for the Future".

1976:  Lecturer to the Board of Directors of Planned Parenthood of San Antonio

1981-89:  Lecturer, Chandler Center for Senior Citizens of San Antonio.

1995-97:  Judge, Churchill Classic Forensic Tournament

1999-00:  Secretary of the Board, International Visitor's Alliance of San Antonio.

1990-06:  Board Member, International Visitor’s Alliance of San Antonio.

CAMPUS COMMITTEES AND OTHER UNIVERSITY ACTIVITIES

1970-06:  Member, Pre-Medical Advisory and Health Professions Committees at Trinity University

1970-72:  Chair, Environmental Studies Committee at Trinity University

1971-72:  Member, Faculty Research and Development Council

1971-72:  Chair, Biophysics Interdepartmental Degree Committee

1972:       Designed and implemented the new Interdepartmental Degree Program in Biophysics

1972:       Designed and implemented the Environmental Studies Degree Program

1972-74:  Chair, Department of Environmental Studies

1972-73:  Chair, Faculty Research and Development Council at Trinity University

1973:       Member, Faculty Investigating Committee

1976:       Speaker, Trinity Freshman Orientation: "How to Enjoy Over-Population—in Ten Easy Lessons"

1976-77:  Member, Faculty Research and Development Council at Trinity University

1976-77:  Member, Search Committee for Selection of Dean of the Faculty of Sciences

1976-77:  Member, Student Housing Projection Committee

1979:       Member, Committee to Restructure the Academic Administration of Trinity University

1979-80:  Acting Chair, Department of Environmental Studies

1979-80:  Chair, Program Committee, Curriculum Council

1980:       Member, Search Committee for Dean of the Division of Science, Mathematics, and Engineering

1980-06:  Coordinator for Registration and Oversight of Trinity Federal Drug Enforcement Administration.

1981-83:  Member, Faculty Development Committee

1982:       Member, Faculty Investigating Committee

1982-06:  Member, Animal Care Facility Committee at Trinity University

1985-86:  Member, Self-Study Committee on Grants and Contract Research at Trinity University

1987:       Chair, Departmental Promotion Committees for Drs. Tom Koppenheffer and Mel Frei.

1988-89:  Chair, Search Committee for Dean of the Division of Science, Mathematics, and Engineering

1988-92:  Member, Faculty Development Committee

1989:       Member, Task Force for Research Development Plan for Division of Science, Math, and Engineering

1991:       Member, Evaluation Committee for Dean of the Division of Science, Mathematics & Engineering

1992:       Member, Howard Hughes Grant Steering Committee

1992-95:  Member, University Standards Committee

1994-95:  Radiation Safety Officer for Trinity University

1995:      Wrote current "Manual of Operating, Safety, and Emergency Procedures for Handling Radioisotopes"

1996-97:  Member, Search Committee for the Semmes Distinguished Professor of Chemistry

1996-99:  Member, Scholarships and Financial Aid Committee

1997-98:  Member, 2nd Search Committee for the Semmes Distinguished Professor of Chemistry

1998-99:  Member, 3rd Search Committee for the Semmes Distinguished Professor of Chemistry

1999-02:  Member, University Distinguished Professor Committee

1999-00:  Member, Presidential Inauguration Committee for Dr. Brazil

1999:       Faculty Marshal, Winter Commencement

2000:       Faculty Marshal, Spring Commencement

2000:       Acting Chair, Trinity University Animal Research Committee

2000-04:  Member, University Fulbright Committee

2000-06:  Senior Marshal, University Commencements and Convocations

2001-06:  Member of the Institutional Review Board

2002-05:  Member of the Faculty Development Committee

2003-06:  Chair, University Commencement and Convocation Committee

2005-06:  Acting Chair, Trinity University Animal Research Committee

 

MISCELLANEOUS ACTIVITIES AND AWARDS

1970:  Invited Lecturer: Trinity University Earth Day Program, "Too Many People".

1970:  Taught a Free University Course entitled "Population and Environment" (by student request).

1972:  KBAT Texas Star Award: Awarded by Radio Station KBAT (San Antonio) for unselfish effort in the field of humanities and public service.

1974:  Luncheon Address entitled "Population Education" to the Southwestern United States regional Planned Parenthood Information & Education Workshop, Austin, Texas, January 10-11.

1974:  Observer: United Nations World Population Conference, Bucharest, Romania, August 17-30.

1976:  Trinity University Academic Orientation lecture entitled "Overpopulation".

1980:  Trinity University Summer Stipend Award: "Inhibition of Ovulation".

1985:  Trinity University Academic Leave Award: "Biochemical Analysis of Ovarian Follicles for Mediators of Inflammation".

1986:  Trinity University Summer Stipend Award: "Ovulation as a Model for Testing the Strength of NSAIDs".

1990:  Trinity University Academic Leave Award: "The Physiology of Ovulation"

1992:  Trinity University Summer Stipend Award: "Application of DNA Technologies to the Study of Ovulation".

1993-01:  Creator and Sponsor of the David R. Bolling Award for Academic Excellence in Premedical Studies

1995:  Trinity University Academic Leave Award: "Application of Differential Display to Ovulation".

1994:  Recipient: United States Patent Number 5,356,876 entitled "Methods of Terminating Pregnancy".

1996:  Trinity University Summer Stipend Award: "A Molecular Method to Study Ovulation".

2000:  Trinity University Academic Leave Award: "Integration of Differential Display Data on Ovarian Gene Expression during Ovulation."  Kyoto University Medical School, Japan

2006:  Trinity University Academic Leave Award:  “Deciphering the Pathway(s) of Ovulation-Related Gene Expression.”  Spring, 2006

 

TRAINEES  (NOTE: Trinity University does not offer graduate programs.)

1967-69:  Robert Stutts completed his Master’s Degree thesis under the mentorship of LLE. He is currently a practicing dentist in Dallas, Texas.

1968-69:  H. Jane Chihal completed her Master’s Degree thesis under the mentorship of LLE. She currently holds the MD/PhD Degrees and is a practicing physician in Plano, Texas.

1972-74:  Sue B. Stacy completed her Master’s Degree thesis under the mentorship of LLE. After raising her family, she recently completed her PhD Degree in Cellular and Structural Biology at the University of Texas Health Science Center in San Antonio, Texas.

1974-76:  Larry Coons completed his Master’s Degree thesis under the mentorship of LLE. He is currently and executive at ROLM, an IBM and Siemens Company, in Austin, Texas.

1974-76:  J.M.R. Rawson, Ph.D., conducted two years of post-doctoral research under the mentorship of LLE. He is currently a practicing physician.

1987-89:  Yasuhiko Higuchi, M.D., Ph.D., conducted two years of post-doctoral research under the mentorship of LLE. He is currently an Assistant Professor in the Department of Obstetrics and Gynecology at Kyorin University School of Medicine, Tokyo, Japan.

1987-90:  Nobuyuki Tanaka, M.D., Ph.D., conducted three years of post-doctoral research under the mentorship of LLE. He is currently an Assistant Professor in the Department of Obstetrics and Gynecology at Kumamoto University Medical School in Kumamoto, Japan.

1989-91:  Tetsuro Kawano, M.D., Ph.D., conducted two years of post-doctoral research under the mentorship of LLE. He is currently a practicing physician in Kumamoto, Japan.

1998-00:  Shinya Yoshioka, M.D., from Kyoto University Medical School worked for 18 months toward his Ph.D. (awarded by Kyoto University) under the mentorship of LLE.

1998-00:  Takeshi Ujioka, M.D., Ph.D., from Kumamoto University Medical School conducted 28 months of post-doctoral research under the mentorship of LLE.

2003:       Zhi Chang, M.D.  Conducted 6 months of post-doctoral research under the mentorship of LLE.

2004-06:  Haruhiro Kondo, M.D., Ph.D., conducted two years of post-doctoral research under the mentorship of LLE.  In October, 2006, he will return to his position of Asst. Prof. of OB/GYN at St. Marianna Univ. Medical school in Tokyo, Japan.

TEACHING RESPONSIBILITIES (full-course responsibility)

1960:  Human Physiology laboratory; Comparative Anatomy laboratory: The University of Texas, Austin

1961:  Human Physiology lecture course: The University of Texas, Austin

1964:  Human Physiology and Anatomy lecture course: The Florida State University, Tallahassee

1965:  Medical Physiology laboratory (partial responsibility): University of Michigan, Ann Arbor

1966:  Introductory Biology lecture and laboratory (2 sections) (remaining courses at Trinity University)

1967:  Introductory Biology lecture and laboratory (3); Scientific Communication lecture

1968:  Introductory Biology laboratory (4); Biology Seminar; Scientific Communication

1969:  Mammalian Physiology lecture and laboratory; Biology Seminar; Scientific Communication

1970:  Mammalian Physiology lecture and lab; Biology Seminar; Interdisciplinary Environmental Science

1971:  Mammalian Physiology lecture and laboratory; Biology Seminar; Environmental Science (2)

1972:  Mammalian Physiology lecture and laboratory; Environmental Science (2); Human Reproduction

1973:  Environmental Studies (2); Environmental Ethics; Human Reproduction & Population Growth

1974:  Environmental Studies (2); Monitoring Pollution; Human Reproduction & Population Growth

1975:  Environmental Studies; Energy, Society & Environment; Environmental Ethics; Human Reproduction

1976:  Environmental Studies (2); Energy, Society & Environ.; Human Reproduction & Population Growth

1977:  Monitoring Environmental Pollution; Environmental Ethics

1978:  Environmental Studies; Environmental Ethics; Human Reproduction & Population Growth

1979:  Environmental Studies; Human Reproduction & Population Growth

1980:  Environmental Studies (2); Adv Topics in Environmental Studies; Human Reproduction & Population

1981:  Environmental Studies (2); Adv Topics in Environmental Studies; Human Reproduction & Population

1982:  Environmental Studies (2); Environmental Ethics; Human Reproduction & Population Growth

1983:  Environmental Studies (2); Human Reproduction & Population Growth; Scientific Communication

1984:  Introductory Biology laboratory (2); Biological Impacts and Issues

1985:  Introductory Biology lecture & lab (2); Environmental Studies; Human Reproduction & Population

1986:  Introductory Biology lecture & laboratory (2); Endocrinology lecture & laboratory

1987:  Introductory Biology lecture & laboratory; Endocrinology lecture & laboratory

1988:  Introductory Biology lecture & laboratory; Endocrinology lecture & laboratory; Biology Seminar

1989:  Introductory Biology lecture & laboratory (2); Endocrinology lecture & laboratory; Biology Seminar

1990:  Introductory Biology laboratory; Endocrinology lecture & laboratory

1991:  Introductory Biology lecture & laboratory (2); Endocrinology lecture & laboratory

1992:  Introductory Biology lecture & laboratory; Endocrinology lecture & laboratory; Biology Seminar

1993:  Introductory Biology lecture (2); Endocrinology lecture & lab; Cell & Molecular Biology laboratory

1994:  Introductory Biology lecture & laboratory (2); Endocrinology lecture & lab; Cell & Molecular lab

1995:  Endocrinology lecture & laboratory; Cell & Molecular Biology laboratory

1996:  Introductory Biology lecture & laboratory (2); Endocrinology lecture & laboratory; Biology Seminar

1997:  Introductory Biology lecture (2); Biology Seminar; Endocrinology lecture & laboratory

1998:  Introductory Biology lecture & lab (2); Endocrinology lecture & lab; Biological Impacts & Issues

1999:  Introductory Biology lecture & lab (2); Endocrinology lecture & lab; Biological Impacts & Issues

2000:  Introductory Biology lecture & lab (2); Endocrinology lecture & lab; Biological Impacts & Issues

2001:  Introductory Biology lecture; Endocrinology lecture & lab; Biol Impacts & Issues; Special Topics

2002:  Introductory Biology lecture; Selected Topics in Molecular Biology; Endocrinology lecture & lab

2003:  Introductory Biology lecture; Biology Seminar; Endocrinology lecture & laboratory

2004:  Biological Impacts & Issues; Endocrinology lecture & lab

2005:  Biological Impacts & Issues; Endocrinology lecture & lab

2006:  Endocrinology lecture & laboratory

PUBLICATIONS

Journal Articles that Underwent Peer Review

Espey, L.L., and H. Lipner (1963) Measurements of intrafollicular pressure in the rabbit ovary. Am. J. Physiol. 205:1067-1072

Espey, L.L., and H. Lipner (1965) Enzyme induced rupture of rabbit Graafian follicle. Am. J. Physiol. 208:208-213

Espey, L.L. (1967) Tenacity of porcine Graafian follicle as it approaches ovulation. Am. J. Physiol. 212: 1397-1401

Espey, L.L. (1967) Ultrastructure of the apex of the rabbit Graafian follicle during the ovulatory process. Endocrinology 81: 267-276

Espey, L.L., and P. Rondell (1967) Estimation of mammalian collagenolytic activity with a synthetic substrate. J. Appl. Physiol. 23: 757-761

Espey, L.L., and P. Rondell (1968) Collagenolytic activity in the rabbit and sow Graafian follicle during ovulation. Am. J. Physiol. 214: 326-329

Espey, L.L. (1970) Effect of various substances on the tensile strength of sow ovarian follicles. Am. J. Physiol. 219: 230-233

Espey, L.L. (1971) Decomposition of connective tissue in rabbit ovarian follicles by multivesicular structures of thecal fibroblasts. Endocrinology 88: 437-444

Espey, L.L. (1971) Multivesicular structures in proliferating fibroblasts of rabbit ovarian follicles during ovulation. J. Cell Biol. 48: 437-442

Espey, L.L., and R.H. Stutts (1972) Exchange of cytoplasm between cells of the membrana granulosa in rabbit ovarian follicles. Biol. Reprod. 6: 168-175

Chihal, H.J., and L.L. Espey (1973) Utilization of the relaxed symphysis pubis of guinea pigs for clues to the mechanism of ovulation. Endocrinology 93: 1441-144

Espey, L.L., And P.J. Coons (1976) Factors which influence ovulatory degradation of rabbit ovarian follicles. Biol. Reprod. 14: 233-245

Espey, L.L., (1976) Distribution of collagenous connective tissue in rat ovarian follicles. Biol. Reprod. 14: 502-506

Rawson, J.M.R., and L.L. Espey (1977) Distribution of electron dense bodies in the surface epithelium of the rabbit ovary during the process of ovulation. Biol. Reprod. 17: 561-566

Espey, L.L., and L. Coons (1977) Quantitation of nexus junctions in the granulosa cell layer of rabbit ovarian follicles during ovulation. J. Cell Biol. 74: 321-325

Espey, L.L., (1978) Ovarian contractility and its relationship to ovulation: A review. Biol. Reprod. 19: 540-551

Espey, L.L. (1980) Ovulation as an inflammatory reaction--A hypothesis. Biol. Reprod. 22: 73-106

Espey, L.L., P.J. Coons, J.M. Marsh and W.J. LeMaire (1981) Effect of indomethacin on preovulatory changes in the ultrastructure of rabbit Graafian follicles. Endocrinology 108: 1040-1048.

Espey, L.L. (1982) Optimum time for administration of indomethacin to inhibit ovulation in the rabbit. Prostaglandins 23: 329-335.

Espey, L.L., V.I. Stein and J. Dumitrescu (1982) Survey of antiinflammatory agents and related drugs as inhibitors of ovulation in the rabbit. Fertil. Steril. 38: 238-247

Espey, L.L. (1983) Comparison of the effect of nonsteroidal and steroidal anti-inflammatory agents on prostaglandin production during ovulation in the rabbit. Prostaglandins 26: 71-78

Espey, L.L. (1983) Inhibition of ovulation in the rabbit by the antimitotic agent, colchicine. Fertil. Steril. 40: 525-529

Shimada, H., H. Okamura, L.L. Espey, and T. Mori (1985) Increase in plasminogen activator in the involuting uterus of the postpartum rat. J. Endocr. 104: 295-298

Espey, L.L., H. Shimada, H. Okamura and T. Mori (1985) Effect of various agents on ovarian plasminogen activator activity during ovulation in PMSG-primed rats. Biol. Reprod. 32: 1087-1094

Narimoto, K., H. Okamura, T. Mori, M. Sakai, L.L. Espey, and K. Ogawa (1985) Cytochemical localization of acid phosphatase in the rabbit ovarian follicle. Acta Histochem. Cytochem. 18: 525-537

Espey, L.L., C. Norris, and D. Saphire (1986) Effect of time and dose of indomethacin on follicular prostaglandins and ovulation in the rabbit. Endocrinology 119: 746-754.

Espey, L.L., D.H. Miller, and H.S. Margolius (1986) Ovarian increase in kinin-generating capacity in PMSG/hCG-primed immature rat. Am.J. Physiol. 251: E362-E365.

Espey, L.L. (1986) Cycloheximide inhibition of ovulation, prostaglandin biosynthesis and steroidogenesis in rabbit ovarian follicles. J. Reprod. Fertil. 78: 679-683.

Yoshimura, Y, L. Espey, Y. Hosoi, T. Adachi, S.J. Atlas, R.B. Ghodgaonkar, N.H. Dubin, and E.E. Wallach (1988) The effects of bradykinin on ovulation and prostaglandin production by the perfused rabbit ovary. Endocrinology 122: 2540-2546.

Espey, L.L., H. Kohda, T. Mori, and H. Okamura (1988) Rat ovarian prostaglandin levels and ovulation as indicators of the strength of non-steroidal anti-inflammatory drugs. Prostaglandins 36: 875-879.

Espey, L.L., N. Tanaka, and H. Okamura (1989) Increase in ovarian leukotrienes during hormonally induced ovulation in the rat. Am. J. Physiol. 256: E753-E759.

Tanaka, N., L. Espey, and H. Okamura (1989) Increase in ovarian blood volume during ovulation in the gonadotropin-primed immature rat. Biol. Reprod. 40: 762-768.

Espey, L.L., N. Tanaka, D.S. Woodard, M.J.K. Harper, and H. Okamura (1989) Decrease in platelet-activating factor during ovulation in the gonadotropin-primed immature rat. Biol. Reprod. 41: 104-110.

Tanaka, N., L.L. Espey, and H. Okamura (1989) Increase in ovarian 15-hydroxyeicosatetraenoic acid during ovulation in the gonadotropin-primed immature rat. Endocrinology 125: 1373-1377.

Espey, L.L., N. Tanaka, V. Winn, and H. Okamura (1989) Increase in ovarian kallikrein activity during ovulation in the gonadotropin-primed immature rat. J. Reprod. Fertil. 87: 503-508.

Higuchi, Y., and L.L. Espey (1989) Pattern of ovarian steroid secretion during ovulation of in vitro perfused rat ovaries varies with method of sampling. J. Reprod. Fertil. 87: 821-828.

Espey, L.L., C. Norris, J. Forman, and T. Siler-Khodr (1989) Effect of indomethacin, cycloheximide, and aminoglutethimide on ovarian steroid and prostanoid levels during ovulation in the gonadotropin-primed immature rat. Prostaglandins 38: 531-539.

Espey, L.L., R.F. Adams, N. Tanaka, and H. Okamura (1990) Effects of epostane on ovarian levels of progesterone, 17B-estradiol, prostaglandin E2, and prostaglandin F2a during ovulation in the gonadotropin-primed immature rat. Endocrinology 127: 259-263.

Espey, L.L., N. Tanaka, R.F. Adams, and H. Okamura (1991) Ovarian hydroxyeicosatetraenoic acids compared to prostanoids and steroids during ovulation in the rat. Am. J. Physiol. 260: E163-E169.

Tanaka, N., L.L. Espey, T. Kawano, and H. Okamura (1991) Comparison of inhibitory actions of indomethacin and epostane on ovulation in the rat. Am. J. Physiol. 260: E170-E174).

Espey, L.L., N. Tanaka, S. Stacy, and H. Okamura (1992) Inhibition of ovulation in the gonadotropin-primed immature rat by exogenous prostaglandin E2. Prostaglandins 43: 67-74.

Espey, L.L. (1992) A review of factors that could influence membrane potentials of ovarian follicular cells during mammalian ovulation. Acta Endocrinologica 126 (Suppl.2): 1-32.

Tanaka, N., L.L. Espey, S. Stacy, and H. Okamura (1992) Epostane and indomethacin actions on ovarian kallikrein and plasminogen activator activities during ovulation in the gonadotropin-primed immature rat. Biol. Reprod. 46:665-670.

Espey, L.L., S. Stacy, H. Hayter, and S. Fujii (1997) Termination of early pregnancy in the rat by a single dose of human menopausal gonadotropin. Early Pregnancy: Biology and Medicine 3:23-26.

Espey, L.L., S. Yoshioka, D. Russell, T. Ujioka, B. Vladu, M. Skelsey, S. Fujii, H. Okamura, J.S. Richards (2000) Characterization of ovarian carbonyl reductase gene expression during ovulation in the gonadotropin-primed immature rat. Biol Reprod 62:390-397.

Espey, L.L., S. Yoshioka, D.L. Russell, R.L. Robker, S. Fujii, J.S. Richards (2000) Ovarian expression of a disintegrin and metalloproteinase with thrombospondin motifs during ovulation in the gonadotropin-primed immature rat. Biol Reprod 62:1090-1095.

Robker, R.L., D.L. Russell, L.L. Espey, J.P. Lydon, B.W. O'Malley, J.S. Richards (2000) Progesterone-regulated genes in the ovulation process: ADAMTS-1 and Cathepsin L proteases. Proc Natl Acad Sci, USA 97:4689-4694.

Espey, L.L., T. Ujioka, D. Russell, M. Skelsey, B. Vladu, R.L. Robker, H. Okamura, J.S. Richards (2000) Induction of early growth response protein-1 gene expression in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Endocrinology 141:2385-2391.

Ujioka, T., D.L. Russell, H. Okamura, J.S. Richards, L.L. Espey (2000) Expression of regulator of G-protein signaling protein-2 (RGS2) gene in the rat ovary at the time of ovulation. Biol Reprod 63:1513-1527.

Yoshioka, S., S. Ochsner, D.L. Russell, T. Ujioka, S. Fujii, J.S. Richards, L.L. Espey (2000) Expression of tumor necrosis factor-stimulated gene-6 (TSG-6) in the rat ovary in response to an ovulatory dose of gonadotropin. Endocrinology 141:4114-4119.

Espey, L.L, S. Yoshioka, T. Ujioka, S. Fujii, and J.S. Richards (2001) 3a -hydroxysteroid dehydrogenase mRNA transcription in the immature rat ovary in response to an ovulatory dose of gonadotropin. Biol Reprod 65:72-78.

Yoshioka, S., S. Fujii, J.S. Richards, and L.L. Espey (2002) Gonadotropin-induced expression of pancreatitis-associated protein-III mRNA in the rat ovary at the time of ovulation. J Endocrinol 174:485-492.

Espey, L.L., J.S. Richards (2002)  Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.  Biol Reprod 67:1662-1670.

Espey, L.L., T. Ujioka, H. Okamura, J.S. Richards (2003) Metallothionein-1  messenger RNA transcription in steroid-secreting cells of the rat ovary during the periovulatory period.  Biol Reprod 68:1895-1902.

Espey, L.L., J. Healy, S. Yoshioka, S. Fujii, J.S. Richards,  (2006)  Expression of epiregulin gene in the same temporal and spatial pattern as cyclooxygenase-2 in the rat ovary during of ovulation.  (in preparation).

Espey, L.L., J. Healy, T. Ujioka, H. Okamura, J.S. Richards  (2006)  Patterns of ovarian expression of the glutathione-related genes glutamylcysteine synthetase and glutathione S-transferase during ovulation in the rat.  (in preparation).

Espey, L.L., T. Ujioka, H. Okamura, J.S. Richards  (2006)  Ovulation-specific expression of membrane factor CD63 in ovarian granulosa cells in the gonadotropin-primed immature rat.  (in preparation).