In our effort to create a strong interdisciplinary program of study we are developing a fully integrated set of introductory science courses that support an undergraduate biology curriculum that is richly quantitative and builds on required introductory courses in chemistry, mathematics, and physics. Our current introductory courses in these departments are fairly conventional in their scope and approach, but none of our current courses provide for students the power of interdisciplinary insights at the levels we seek to achieve. The goals of the revision process are to make linkages between biology and other disciplines that are compelling and apparent to our students, to reinforce those linkages at multiple points in multiple courses of our introductory sequences, to teach biology students the ability to apply quantitative methods and reasoning to biology at substantially higher levels than they currently use, and to stimulate an interest in the interface between biology and these disciplines.