The Cadherin Molecule:Ca++ - dependent cell-cell adhesion

• Single pass transmembrane protein

  • E and N cadherin
  • 750 aa

• Extracellular

  • five domains, 3 with Ca++ binding
  • 100 aa per domain

• Intracellular

  • attachment sequence: catenin, X, actin cytoskeleton

• Homophilic binding

Alberts et al. 3rd, p 966

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