Integrins: transmembrane heterodimers

• 25+ species of heterodimer

• Different cells, different dimer arrangements

• a = 140 kd, b = 100 kd

• Blood cells can reorganize

• Indentified with genetic diseases

  • leucocyte adhesion deficiency

    • bacterial infections
  • Glanzmann’s disease

    • bleeding

Alberts et al. 3rd, p 996

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