Adiponectin



Description

Adiponectin is a hormone produced by the adipose tissue involved in the regulation of glucose and fatty acid oxidation. Serum adiponectin correlates with decreased free fatty acid blood concentrations and reduced body mass index or body weight; adiponectin protects from vascular diseases by inhibiting local proinflammatory signals, preventing preatherogenic plaque formation, and by impeding arterial wall thickening (Schondorf, Maiworm et al. 2005). Modulation of the circulating adiponectin concentration is observed in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus and atherosclerosis, and it also occur in pathologies such as cancer and rheumatoid arthritis (Brochu-Gaudreau, Rehfeldt et al. 2010). We have not been able to find reagents that recognize MAR adiponectin.


Alignment

Protein alignment for human, rhesus macaque and marmoset adiponectin:

image of Protein alignment for human, rhesus macaque and marmoset adiponectin

 

Protein alignment for marmoset, owl monkey, and squirrel monkey adiponectin:

Protein alignment for marmoset, owl monkey, and squirrel monkey adiponectin

 

References

  • Brochu-Gaudreau, K., C. Rehfeldt, R. Blouin, V. Bordignon, B. D. Murphy and M. F. Palin (2010). "Adiponectin action from head to toe." Endocrine 37(1): 11-32.
  • Schondorf, T., A. Maiworm, N. Emmison, T. Forst and A. Pfutzner (2005). "Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk." Clin Lab 51(9-10): 489-494.

 

Status

Several monoclonal antibody pairs have been developed and are being validated.