CD69


 

Description

CD69 is a membrane‐bound, type II C‐lectin receptor, usually identified as a classical early marker of lymphocyte activation, due to its rapid appearance on the surface of the plasma membrane after stimulation. CD69 is expressed by several subsets of tissue resident immune cells, including resident memory T (TRM) cells and gamma delta (gd) T cells, and is therefore considered a marker of tissue retention. Recent evidence has revealed that CD69 regulates the differentiation of regulatory T cells (Treg) as well as the secretion of IFN‐g, IL‐17, and IL‐22 (Cibrian and Sanchez-Madrid 2017).

 

Alignment

Protein alignment for human, rhesus macaque and marmoset CD69:

image of Protein alignment for human, rhesus macaque and marmoset CD69

 

Protein alignment for marmoset, owl monkey, and squirrel monkey CD69:

Protein alignment for marmoset, owl monkey, and squirrel monkey CD69

 

References

  • Cibrian, D. and F. Sanchez-Madrid (2017). "CD69: from activation marker to metabolic gatekeeper." Eur J Immunol 47(6): 946-953.

 

Status

Several monoclonal antibody have been developed and are being validated.