CXCL10 (IP-10)


 

Description

IFN-g-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II interferons (IFNs) and lipopolysaccharide (LPS,) is a chemoattractant for activated T cells. Expression of IP-10 is seen in many Th1-type inflammatory diseases, where it plays an important role in recruiting activated T cells into sites of tissue inflammation (Dufour, Dziejman et al. 2002). IP-10 has been recently identified as a sensitive biomarker for inflammatory conditions including among others, development and treatment of tuberculosis (Ruhwald, Bjerregaard-Andersen et al. 2009, Goosen, Cooper et al. 2015), acute respiratory infections (Hayney, Henriquez et al. 2017), Kawasaki disease (Ko, Kuo et al. 2015), viral infections (Quint, Donaldson et al. 2010), and cystic fibrosis exacerbation (Solomon, Frederick et al. 2013). There are no available immunological reagents for MAR IP-10.

 

Alignment

Protein alignment for human, rhesus macaque and marmoset IP-10:

image of Protein alignment for human, rhesus macaque and marmoset CXCL10 (IP-10)

 

Protein alignment for marmoset, owl monkey, and squirrel monkey IP-10:

Protein alignment for marmoset, owl monkey, and squirrel monkey IP-10

 

References

  • Dufour, J. H., M. Dziejman, M. T. Liu, J. H. Leung, T. E. Lane and A. D. Luster (2002). "IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking." J Immunol 168(7): 3195-3204.
  • Goosen, W. J., D. Cooper, M. A. Miller, P. D. van Helden and S. D. Parsons (2015). "IP-10 Is a Sensitive Biomarker of Antigen Recognition in Whole-Blood Stimulation Assays Used for the Diagnosis of Mycobacterium bovis Infection in African Buffaloes (Syncerus caffer)." Clin Vaccine Immunol 22(8): 974-978.
  • Hayney, M. S., K. M. Henriquez, J. H. Barnet, T. Ewers, H. M. Champion, S. Flannery and B. Barrett (2017). "Serum IFN-gamma-induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults." J Clin Virol 90: 32-37.
  • Ko, T. M., H. C. Kuo, J. S. Chang, S. P. Chen, Y. M. Liu, H. W. Chen, F. J. Tsai, Y. C. Lee, C. H. Chen, J. Y. Wu and Y. T. Chen (2015). "CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease." Circ Res 116(5): 876-883.
  • Quint, J. K., G. C. Donaldson, J. J. Goldring, R. Baghai-Ravary, J. R. Hurst and J. A. Wedzicha (2010). "Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD." Chest 137(4): 812-822.
  • Ruhwald, M., M. Bjerregaard-Andersen, P. Rabna, J. Eugen-Olsen and P. Ravn (2009). "IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay." BMC Res Notes 2: 19.
  • Solomon, G. M., C. Frederick, S. Zhang, A. Gaggar, T. Harris, B. A. Woodworth, C. Steele and S. M. Rowe (2013). "IP-10 is a potential biomarker of cystic fibrosis acute pulmonary exacerbations." PLoS One 8(8): e72398.

 

Status

Several monoclonal antibody pairs have been developed and are being validated.