Granzyme B


 

Description

The predominant pathway used by CD8+ T cells to kill pathogen-infected cells is granule exocytosis, involving the release of Granzyme B (GB). GB is a serine protease which cleaves various caspases inside the target cell, this triggers apoptosis and death of the infected cell. GB release is a hallmark of activated cytotoxic T cells and is thus an important marker to measure in vaccine development and when studying correlates of protection against intracellular infections (Hiebert and Granville 2012).

 

Alignment

Protein alignment for marmoset, owl monkey, and squirrel monkey granzyme B:

Protein alignment for marmoset, owl monkey, and squirrel monkey granzyme B

 

References

  • Hiebert, P. R. and D. J. Granville (2012). "Granzyme B in injury, inflammation, and repair." Trends Mol Med 18(12): 732-741.

 

Status

Mice have been immunized with recombinant marmoset protein.