Interleukin-4 (IL-4)


 

Description

IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector Th2-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FceRl+ mast cells and basophils. IL-4 plays an important role in the development of certain immune disorders, particularly allergies and some autoimmune diseases (Brown and Hural 2017). There are no available assays for marmoset IL-4.

 

Alignment

Protein alignment for human, rhesus macaque and marmoset IL-4:

image of Protein alignment for human, rhesus macaque and marmoset Interleukin-4 (IL-4)

 

Protein alignment for marmoset, owl monkey, and squirrel monkey IL-4:

Protein alignment for marmoset, owl monkey, and squirrel monkey IL-4

 

References

  • Brown, M. A. and J. Hural (2017). "Functions of IL-4 and Control of Its Expression." Crit Rev Immunol 37(2-6): 181-212.

 

Status

Several monoclonal antibody pairs have been developed and are being validated.