• Dr. Binder joined the Trinity faculty in 2023. Prior to coming to Trinity, he was a postdoctoral fellow at the Yale School of Medicine. He earned a Bachelor of Science in Neuroscience and a Bachelor of Arts in Philosophy from Regis University before obtaining his Ph.D. in Neuroscience from Baylor University.

    • Post-doctoral Fellow Yale University
    • Ph.D. Baylor University
    • B.S. Regis University 

    • Binder, MS., Bordey, A. (2023). Semi-natural housing rescues social behavior and reduces repetitive exploratory behavior of BTBR autistic-like mice. Scientific Reports.
    • Binder, MS., Bordey, A. (2023). The novel somatosensory nose-poke adapted paradigm (SNAP) is an effective tool to assess differences in tactile sensory preferences in autistic-like mice. eNeuro.
    • Binder, MS., Dalton, GJ, Hodges, SL., Lugo, JN. (2020). NS-Pten adult knockout mice display both spectral and qualitative changes in urine-induced ultrasonic vocalizations. Behavioral Brain Research, 378. doi: https://doi.org/10.1016/j.bbr.2019.112189
    • Binder, MS., Lugo JN. (2017). NS-Pten knockout mice show sex-and age-specific differences in ultrasonic vocalizations. Brain Behav. 2017;e00857. https://doi.org/10.1002/brb3.857
    • Binder, MS., Prankse, ZP., Lugo, JN. (2021). Evaluating the DeepSqueak and Mouse Song Analyzer Vocalization Analysis Systems in C57BL/6, FVB.129, and FVB Neonates. Journal of Neuroscience Methods.
       

    The Binder Lab investigates how early-life seizures disrupt neurodevelopment and contribute to long-term neurological and psychiatric comorbidities, including mood disorders, socio-communicative deficits, autism spectrum disorder, and cognitive impairment. A central focus of the lab is determining how alterations in neural connectivity, together with dysregulation of the mTORC1 and MEK/ERK signaling pathways, drive these outcomes across development. To address these problems, the lab integrates behavioral analyses with immunohistochemical, pharmacological, and advanced imaging approaches. The overarching goal of this work is to identify the mechanisms underlying seizure-associated neurodevelopmental dysfunction then translate these findings into therapeutic strategies that improve individual’s long-term quality of life.

    • Introduction to Neuroscience
    • Neuroscience Laboratory
    • Clinical Neuroanatomy: The Pathophysiology of Disease