Adam Urbach, Ph.D.
- Professor , Chemistry
I'm a native Texan, and as a college student at UT Austin I found my passions for chemistry, teaching, and service, and I met my future wife. I trained in the research areas of medicinal chemistry, structural biology, biophysics, and nanotechnology before starting at Trinity in 2004. My research group of Trinity students has established methods for binding peptides and proteins predictively on the basis of the amino acid sequence, and we are now pursuing applications in the areas of biosensing, protein engineering, and drug formulation. The science is interesting and fun, but my real passion is teaching organic chemistry and mentoring research students. I am also heavily invested in service to Trinity and to the science community, and I am devoted to my family.
*indicates Trinity student or alumni co-author
"Molecular Recognition of Methionine-Terminated Peptides by Cucurbituril” Zoheb Hirani,* Hailey F. Taylor,* Emily F. Babcock,* Andrew T. Bockus, C. Daniel Varnado, Jr., Christopher W. Bielawski, Adam R. Urbach, “ (Article) Journal of the American Chemical Society, 2018, v. 140, 12263-12269.
"Cucurbituril-Tetramethylrhodamine Conjugate for Direct Sensing and Cellular Imaging" Andrew T. Bockus, Lauren C. Smith,* Amy G. Grice,* Omar A. Ali,* Carolyn C. Young,* William Mobley,* James L. Roberts, Brittany Vinciguerra, Lyle Isaacs, and Adam R. Urbach, (Article) Journal of the American Chemical Society 2016, v. 138, 16549-16552.
"Sequence-Specific, Nanomolar Peptide Binding via Cucurbituril-Mediated Folding and Inclusion of Neighboring Side Chains” Lauren C. Smith,* David G. Leach,* Brittney E. Blaylock,* Omar A. Ali,* and Adam R. Urbach, (Article) Journal of the American Chemical Society, 2015, v. 137, 3663-3669. Selected as a Spotlight Article.
"Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbituril" Min Hyeon Shin, Jong Wha Lee, William Mobley,* Adam R. Urbach, and Hugh I. Kim, Journal of the American Chemical Society, 2015, V. 137, 15322-15329.
"Sequence-Specific Inhibition of a Nonspecific Protease" Leigh A. Logsdon* and Adam R. Urbach, Journal of the American Chemical Society, 2013, v. 135, 11414-11416.
"Molecular Recognition of Insulin by a Synthetic Receptor" Jordan M. Chinai*, Alexander B. Taylor, Lisa M. Ryno*, Nicholas D. Hargreaves*, Christopher A. Morris*, P. John Hart, and Adam R. Urbach, Journal of the American Chemical Society, 2011, v. 133, 8810-8813. Selected as a Spotlight Article.
"Determining Protease Substrate Selectivity and Inhibition by Label-Free Supramolecular Tandem Assays" Garima Ghale, Vijayakumar Ramalingam, Adam R. Urbach, and Werner M. Nau, Journal of the American Chemical Society, 2011, v. 133, 7528-7535.
"Nanomolar Binding of Peptides Containing Noncanonical Amino Acids by a Synthetic Receptor" Leigh A. Logsdon,* Christopher L. Schardon,* Vijayakumar Ramalingam, Sharon K. Kwee,* and Adam R. Urbach, Journal of the American Chemical Society, 2011, v. 133, 17087-17092.
Urbach's work has been supported by $2.8M in grants from federal agencies and private foundations including the Welch Foundation, the National Science Foundation (CAREER, RUI, and MRI programs), the National Institutes of Health (R15 program), Research Corporation for Science Advancement (Cottrell Scholar, LEAD, and Cottrell Scholar Collaborative programs), the Camille and Henry Dreyfus Foundation, and the American Chemical Society Petroleum Research Fund.